The changes of adhesion molecule on myocardium during mitral valve replacement operation on beating heart
- VernacularTitle:心脏跳动中二尖瓣置换术心肌组织黏附分子的变化
- Author:
Shikang LI
;
Wei HE
;
Jianhui HUAN
- Publication Type:Journal Article
- Keywords:
Heart valve prosthesis implantation Inflammation Intercellular adhesion molecule-1
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Investigate the changes of adhesion molecule on myocardium in patients during mitral valve replacement(MVR) operation on beating heart. Methods Patients were divided into two groups. There were 16 patients in control group (aorta crossclamped and middle hypothermic) and 14 patients in experimental group (aorta unclamped and moderate hypothermic). Samples of right atrial were obtained before CPB, 30 min after CPB. Immunohistochemistry were employed to dectect the expression of ICAM-1 and VCAM-1 on cardiac myocytes. Results Comparing with those before CPB, ICAM-1 and VCAM-1 on cardiac myocytes and myocardial vascular endothelial cells increase significantly in both groups(P
