Effects of Xinshuaiheji on Rats with Heart Failure after Acute Myocardial Infarction
- VernacularTitle:心衰合剂对心肌梗死后心力衰竭大鼠的影响
- Author:
Mei DAI
;
Qingxiang WEN
;
Junren HE
- Publication Type:Journal Article
- Keywords:
Xishuaiheji;
heart failure;
myocardial infarction;
angiotensin Ⅱ
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Xinshuaiheji (XSHJ) on cardiac function, plasma angiotensin Ⅱ (AngⅡ) and histomorphology in rats with heart failure after acute myocardial infarction. Methods A model of heart failure (HF) induced by myocardial infarction (MI) in rats was made, 10 days after MI, rats were treated for 4 weeks with bidist Water, Captopril, high dosage of XSHJ, low dosage of XSHJ. The effects of Xinshuaiheji on cardiac function (stroke volume, SV, cardiac output, CO, cardiac index, CI ) and AngⅡ were observed. We also observed and compared the changes of heart weight/body weight ratio (HW/BW), ratio of ventricular wall thinning in MI. Results After treatment with XSHJ, the cardiac function (SV, CO, CI) of HF rats improved (P
