Effects of anti-CXCR4 monoclonal antibody 12G5 on adhesion and invasion of gastric cancer cells
- VernacularTitle:抗CXCR4单克隆抗体12G5对胃癌细胞粘附与侵袭的影响
- Author:
Jun LUO
- Publication Type:Journal Article
- Keywords:
SDF-1/CXCR4;
Monoclonal antibody;
SGC7901 cells;
Cell adhesion;
Cell invasion
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of anti-CXCR4 monoclonal antibody 12G5 on adhesion and invasion of SGC7901 cells.Methods:The effects of 12G5(5?g/ml,10?g/ml and 20?g/ml, respectively)on the adhesive、invasive and migrative abilities of SGC7901 cells were explored by MTT and Transwell chamber. Results:(1)12G5 showed a time/dose-dependent inhibition effect on SGC7901 cells adhering Matrigel,and the adhesion of gastric cancer cells was inhibited on the concentration of 10?g/ml of 12G5, and compared with untreated group,adhesion of SGC7901 cells was signficantly lower(P
