EXPRESSIONS OF THE EZH2 PROTEIN IN THE CARCINOMA OF ESOPHAGUS
- VernacularTitle:EZH2蛋白在食管癌组织中的表达
- Author:
Yan PENG
;
Haibin CHEN
- Publication Type:Journal Article
- Keywords:
EZH2 protein;
Esophageal carcinoma;
Immunohistochemistry;
Western blotting;
Human
- From:
Acta Anatomica Sinica
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of enhancer of zeste(EZH2) in carcinoma of esophagus and its potential significance. Methods The expression and distribution of EZH2 were determined on the esophageal squamous carcinoma,adenocarcinoma by using immunohistochemistry.We then detected EZH2 protein expression in the esophageal squamous carcinoma, paracarcinomatous and normal tissues by Western blotting.Results The immunohistochemical staining showed EZH2 protein was highly expressed in esophageal squamous carcinoma and adenocarcinoma tissues.The positive staining was observed in the nuclear region.Normal tissues and corresponding paracarcinomatous tissues were stained weakly.Western blotting analysis showed that the strongest positive signals were detected in the esophageal squamous carcinoma(P
