Research on the protocol of limited ovarian stimulation to prevent ovarian hyperstimulation syndrome
- VernacularTitle:限制性促排卵方案预防卵巢过度刺激综合征的探索性研究
- Author:
Yimin ZHU
;
Huijuan GAO
;
Ronghuan HE
;
Hefeng HUANG
- Publication Type:Journal Article
- Keywords:
Ovulation induction;
Ovarian hyperstimulation syndrome;
Polycystic ovarian syndrome;
Embryo transfer;
Fertilization in vitro
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether the limited ovarian stimulation (LOS) could avoid the severe ovarian hyperstimulation syndrome (OHSS) in patients with high risk of OHSS. Methods Ten infertile patients were diagnosed as polycystic ovarian syndrome(PCOS) with high risk of OHSS. All of them were arranged LOS cycles, a long-induction protocol using gonadotropin releasing hormone agonist (GnRHa) for controlled ovarian hyperstimulation. A full dose of human chorionic gonadotropin (10 000 U) was administered when the leading follicle reached a mean diameter of 12.0-14.5 mm. Oocytes were retrieved 36 hours later, followed by conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and embryo transfer. Results Ten patients produced 11-35 oocytes, including 4-28 oocytes of metaphase Ⅱ. Embryos were transferred in all of ten patients and eight clinical pregnancies were diagnosed. Unfortunately, ectopic pregnancy occurred in one of the patients. None of them experienced the symptoms of OHSS. Conclusions LOS may play a valuable role in preventing OHSS and achieving enough mature oocytes for the patients of PCOS. Furthermore, this protocol would not reduce the pregnancy rate of the patients.
