Pharmacodynamics Study of Rupixiao Tablets Prepared by Optimized Process
- VernacularTitle:工艺优化前后乳癖消片的主要药效学研究
- Author:
Guobing XU
- Publication Type:Journal Article
- Keywords:
Rupixiao Tablets;
Hyperplasia of mammary glands;
Sexual hormone
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of Rupixiao Tablets prepared by or not by optimized process on hyperplasia of mammary glands in rats.Methods Rat models with hyperplasia of mammary glands were established by injection of estradiol benzoate and progesterone.After treatment with Rupixiao Tablets for four weeks,the mammary gland tissues were sliced for pathological examination,uterine index and ovarian index were measured,the serum contents of estradiol, progesterone,testosterone,prolactin,luteining hormone and follicle stimulating hormone were determined by radioim- munoassay method.Results Compared with the model group,the symptom of red and swollen nipples was relieved,hy- perplasia of lobule of mammary gland and gland vacuole and duct were reduced,the levels of estradiol,progesterone, testosterone,luteining hormone were reduced and prolactin was increased in all treatment groups.Rupixiao Tablets pre- pared by two kinds of process both had evidently therapeutic effect,and the differences of the compared indexes were in- significant.Conclusion Rupixiao Tablets prepared by optimized process has therapeutic effect on hyperplasia of mamma- ry glands in rats and has no significant differences in the main pharmacodynamics indexes when compared to those of the original preparation.
