Stromal cell-derived factor-1 (SDF-1) expression in the oral squamous cell carcinoma.
10.5125/jkaoms.2010.36.1.1
- Author:
Kyung Wook KIM
1
;
Se Jin HAN
;
Kyu Seob ROH
Author Information
1. Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Korea. kkwoms@dku.edu
- Publication Type:Original Article
- Keywords:
Chemokine;
Chemokine CXCL12 (SDF-1);
Oral squamous cell carcinoma
- MeSH:
Breast Neoplasms;
Carcinoma in Situ;
Carcinoma, Squamous Cell;
Chemokine CXCL12;
Chemokines;
Cholangiocarcinoma;
Glioblastoma;
Humans;
Lung Neoplasms;
Melanoma;
Neoplasm Metastasis;
Pancreatic Neoplasms;
Receptors, Chemokine;
RNA, Messenger;
Up-Regulation
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2010;36(1):1-6
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Chemokines are structurally related, small polypeptide signaling molecules that bind to and activate a family of transmembrane G proteincoupled receptors, the chemokine receptors. Recently, interaction between the chemokine receptor CXCR4 and its ligand, stromal cell-derived factor 1 (SDF-1 or CXCL12), has been found to play an important role in tumorigenicity, proliferation, metastasis and angiogenesis in many cancers such as lung cancer, breast cancer, melanoma, glioblastoma, pancreatic cancer and cholangiocarcinoma. Hence, the goal of this study is to identify the correlation of clinicopathological factors and the up-regulation of SDF-1 expression in oral squamous cell carcinoma. MATERIAL AND METHODS: We studied the immunohistochemical staining of SDF-1, quantitative RT-PCR (qRT-PCR) of SDF-1 gene in 20 specimens of 20 patients with oral squamous cell carcinoma. RESULTS: 1. In the immunohistochemical study of poor differentiated and invasive oral squamous cell carcinoma, the high level staining of SDF-1 was observed. And the correlation between immunohistochemical SDF-1 expression and tumor nodes metastases (TNM) classification of specimens was significant.(chi-square test, P < 0.05) 2. In the SDF-1 gene qRT-PCR analysis, SDF-1 expression was more in tumor tissue than in carcinoma in situ tissue. Paired-samples analysis determined the difference of SDF-1 mRNA expression level between the cancer tissue and the carcinoma in situ tissue.(Student's t-test, P < 0.05) CONCLUSION: These findings suggest that up-regulation of the SDF-1 may play a role in progression and invasion of oral squamous cell carcinoma.
