Influence of Total Rhizoma Panacis Japonica Saponins on Hemorheology in Rats with Occlusion of the Middle Cerebral Artery
- VernacularTitle:竹节参总皂苷对中动脉栓塞模型大鼠血液流变学的影响
- Author:
Hui ZHAO
;
Jia LI
;
Yang MU
- Publication Type:Journal Article
- Keywords:
total rhizoma panacis japonica saponins (tRPJS);
hemorheology;
cerebral ischemia
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of total rhizoma panacis japonica saponins (tRPJS) on hemorheology in rats with occlusion of the middle cerebral artery. Methods Ischemia rat models were made by using the method of thread inserting right middle cerebral artery occlusion. The effects of tRPJS on whole blood viscidity, erythrocyte deformability and erythrocyte congregate in model rats were observed. Results tRPJS 200, 100, 50 mg/kg could significantly improve the erythrocyte deformability, reduce whole blood viscidity and erythrocyte congregate. Conclusion tRPJS can improve the hemorheology after cerebral ischemia. It may be one of the mechanisms for tRPJS in treating ischemic stroke.
