Study of Yanshu Injection on Enhancing Effects of Chemotherapy and Reducing Toxicity and Immune Effect in Tumor-bearing Mice
- VernacularTitle:岩舒注射液对荷瘤小鼠化疗增效减毒及免疫功能的影响
- Author:
Yulan XIONG
;
Yanli WANG
;
Jianhui SUN
- Publication Type:Journal Article
- Keywords:
Yanshu injection;
chemotherapy;
effect improvement;
toxicity-reducing;
immunie regulation
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Yanshu injection for the chemotherapy, toxicity- reducing and immunization in mice implanted tumor. Methods Bulid up the mice models with S180 solid tumor transfered by ascites tumor, and observe the effect on tumor weight, blood WBC and bone marrow nucleated cells when combined use Yanshu injection and cyclophospamide (Cy). Determine OD value of plague forming cell by spectrophotometry, measure T-lymphocyte transformation by 3H-TDR incorporation, and survey natural killer cell (NKC) activity by colorimetric method, all these can help to study the role of Yanshu injection on the immune effect in the mice models. Results Yanshu injection can strengthen antitumor activity of Cy, antagonize the inhibition of Cy to WBC and bone marrow nucleated cell, improve OD value of plague forming cell, promote T-lymphocyte transformation, also can enhance NKC activity and killing rate. Conclusion Yanshu injection can increase the chemotherapeutic effects, reduce toxin, and enhance immune function of mice implanted tumor.
