The effect of hyaluronic acid on anti-inflammatory action in mouse.
10.5125/jkaoms.2010.36.1.16
- Author:
Sang Kyun KIM
1
;
Hyung Seok LEE
;
Kwang Seob BYEON
;
Young Joo LEE
;
Soon Min HONG
;
Mee Ra CHOI
;
Jun Woo PARK
Author Information
1. Graduate student of Hallym University, College of Medicine, Hallym University, Korea.
- Publication Type:Original Article
- Keywords:
Hyaluronic acid;
Anti-inflammatory agent;
Mice
- MeSH:
Animals;
Cytokines;
Dinoprostone;
Ear;
Edema;
Electrons;
Gene Expression;
Hyaluronic Acid;
Inflammation;
Light;
Mice;
RNA, Messenger
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2010;36(1):16-22
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1beta(IL-1beta), cyclooxygenase2 (COX-2) and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse. MATERIAL AND METHODS: Mice of this study were devided into 4 groups: Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply). RESULTS: Hyaluronic group showed less expressions of IL-1beta, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope. Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope. CONCLUSION: It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.
