Comparison of oral Sildenafil and intravenous prostaglandin E_1 in treatment of pulmonary hypertension associated with congenital heart defects after cardiac surgery
- VernacularTitle:西地那非与前列地尔治疗先天性心脏病术后肺动脉高压的疗效对比
- Author:
Fan TONG
;
Lizhong DU
;
Liping SHI
- Publication Type:Journal Article
- Keywords:
Sildenafil;
Hypertension;
pulmonary;
Heart defect,congenital;
Cardiopulmonary bypass
- From:
Chinese Journal of Emergency Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of oral Sildenafil(SIL)and intravenous prostaglandin E_1(Alprostadil,PGE_1)in treatment of postoperative pulmonary hypertension(PH)associated with congenital heart defects(CHD).Methods Data were collected from 24 children with postoperative mPAP≥35 mmHg in our hospital between August 2004 and March 2005.These children were randomly divided into three groups:8 children(group A)initially received SIL(0.35 mg/kg,orally by nasal gastric tube),followed by the addition of intravenous PGE_1(20 ng/kg per min)at 40 min.The second group of 8 children(group C)initially received intravenous PGE_1 followed by the addition of SIL at 20 min(dose as above).And remains(group B)were placebo-controlled.The changes of hemodynamic variables,arterial blood gas,lung static compliance(C)and work of breathing(W)were measured after drugs were given.Results Compared with group B,the mPAP and mPAP/mSAP was significantly reduced(P
