Effect of Dan Zhi Xiaoyao San and Its Extracts on Hypothalamus-Pituitary Gland-Adrenal Gland Secretion in Rats with Chronic Psychological Stress
- VernacularTitle:丹栀逍遥散及其提取物对慢性应激大鼠下丘脑—垂体—肾上腺轴分泌的影响
- Author:
Lili WU
;
Can YAN
;
Junfang SU
;
Zhiwei XU
;
Wenzhu WANG
- Publication Type:Journal Article
- Keywords:
DAN ZHI XIAOYAO SAN/pharmacology;
DAMAGE INDUCED BY PSYCHOLOGICAL STRESS/TCD therapy;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To investigate the effects of Dan Zhi Xiaoyao San(DZXS) and its extracts on hypothalamic corticotropin releasing hormone(CRH) and plasma corticosterone(CORT) in rats with chronic psychological stress.【Methods】Wistar rats were randomized into 6 groups: A(normal control),B(model control),C (extract of DZXS extracted by water extraction and alcohol precipitation,3.608?g/kg),D(extract of DZXS extracted by petroleum ether,0.087?g/kg),E(extract of DZXS extracted by polysaccharide,2.20?g/kg) and F(DZXS 14.4?g/kg).Except group A,the rat models of chronic multi-phase psychological stress were established in other groups by improved Cart method.Groups A and B were given normal saline,and groups C,D and E were given the corresponding drugs according to the experimental design.Hypothalamic CRH and plasma CORT contents were examined to explore the therapeutic mechanism.【Results】Compared with group A,hypothalamic CRH and plasma CORT contents were increased in group B;hypothalamic CRH content was decreased in groups C,E and F(P
