Endurance of normal New Zealand Rabbits' brain tissue after high intensity focused ultrasound ablation
- VernacularTitle:兔脑在高强度聚焦超声作用下的耐受性研究
- Author:
Wei BIAN
- Publication Type:Journal Article
- Keywords:
High Intensity Focused Ultrasound;
Endurance;
Brain tissue
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The purpose of this study is to determine if HIFU is feasible for the treatment of brain diseases by observing New Zealand Rabbits' reaction,living status and variation in microscope after different dosages of ablation.Methods:By using the same total time of HIFU exposure,we took different divided time to sonicate localized brain tissues of 24 New Zealand Rabbits for several times,to observe the rabbits' reaction and living status.All animals were sacrificed after 5 weeks.Then we applied TTC stain to observe the gross changes and HE stain to observe histological changes in microscope.Results:During the observation period,the rabbits' living status was apparently getting worse when the single exposure was ≥ 20 second(s).The times of exposure were not correlated with living status.According to our observation,the rabbits could tolerate the dose of HIFU exposure
