The expression change of aquaporin 1 in hyperoxic lung injury
- VernacularTitle:水通道蛋白1在高氧肺损伤中的表达变化
- Author:
Jie HAO
- Publication Type:Journal Article
- Keywords:
Aquaporin;
Hyperoxia;
Lung injury;
Oedema
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
0.95)or room air(O2=0.21,respectively.The distributions of AQP1 in the lung tissues were detected by immunohistochemistry and their mRNA expressions were measured by RT-PCR.In addition,the wet-to-dry weight ratio(W/D),the protein content of bronchoalveolar lavage fluid(BALF),lung leak index,histological changes of hyperoxia-induced lung injury were measured respectively.Results:Light microscopic findings in the hyperoxia group including oedema,hemorrhage and extensive inflammatory cells in the lungs were observed.The lung W/D?the protein content in BALF and the lung leak index in hyperoxia group were significantly higher than those in room air group.The expressions of AQP1 mRNA in the lungs were significantly decreased at 3d of hyperoxia-exposure,minimized at 7d and increased from 14d(P
