Effects of cisplatin,oxymatrine on the cell growth and telomerase activity of QGY hepatoma cells
- VernacularTitle:顺铂、氧化苦参碱对肝癌QGY细胞生长及端粒酶活性的影响
- Author:
Song HE
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Telomerase;
Cisplatin;
Oxymatrine
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the anti-cancer mechanism of cisplatin,oxymatrine by observing their effects on telomerase activity.Methods:The inhibition of proliferation in QGY cells were estimated by MTT-test.Distribution of cell cycle and apoptosis were analysed using flow cytometry.The changes of telomerase activity were detected by PCR-ELISA method.Results:These two drugs could inhibit the proliferation of QGY cells,block the cell cycle,induce its apoptosis and inhibit the activity of telomerase.Conclusion:The inhibition of telomerase activity may be one of the mechanisms for the anti-cancer effect of the two drugs.
