Effect of Cholecystokinin on Electricity Activity of Gastric Distention Related Neurons in NTS
- VernacularTitle:CCK对孤束核中胃扩张相关神经元电活动的影响
- Author:
Fang WANG
- Publication Type:Journal Article
- Keywords:
Cholecystokinin;
The Nucleus of Solitary Tract;
Gastric Distention
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of cholecystokinin on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius.Methods: The effects of gastric distention and intravenous CCK on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius were investigated in urethane anesthetized rats.Results:Intravenous CCK could obviously influence the spontaneous activity of gastric distention related neurons in the nucleus of tractus solitarius.Intravenous CCK could increase the discharge of gastric distention(GD)excited neurons(9/14)and decrease the discharge of GD inhibited neurons(5/14) in NTS.Howerer,the effect of CCK on gastric distention-induced discharge of GD related neurons was always inhibitory.Conclusion:Circulating CCK and gastric distention have both excitatory and inhibitory effects on the electricity activity of gastric distention related neurons in NTS,but the effect of CCK on gastric distention-induced discharge of GD related neurons is inhibitory.The effect of gastric distention on spantenous discharge of neurons in NTS is similar to circulating CCK.
