Protection of little dosage of Desamethasone to pulmonary function on acute lung injury model
- VernacularTitle:创建急性肺损伤模型探讨小剂量地塞米松对肺脏的保护作用
- Author:
Ling LIANG
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
Desamethasone;
Pulmonary function
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the pretection of small dosage desamethasone to pulmonary function on acute lung injury model.Methods:54 male SD rats were divided randomly into control group,injury group and therapeutic group.Major observed marker consisted of count of cell sum,total protein level and TNF-? level of bronchoalveolar douche solution.Secondary marker consisted of lung coefficient,PAO2,TNF-? level in blood serum and histopathologic examination.Results: Alveolar texture in therapeutic group existed yet,but alveolar interval increased thickness,neutrophilic granulocyte infiltration relieved obviously,and a little bleeding in alveolar cavity.PAO2 in therapeutic group was higher than that of injured group(P
