Genetic aberrations and human papillomavirus status in vulvar squamous cell carcinomas
- VernacularTitle:外阴鳞状细胞癌组织中染色体变异与人乳头状瘤病毒感染状态的关系
- Author:
Ling OUYANG
;
Shulan ZHANG
;
Xin WANG
- Publication Type:Journal Article
- Keywords:
Vulvar neoplasms;
Carcinoma,squamous cell;
Chromosomes;
Variation(genetics);
Nucleic acid hybridization;
Papillomavirus infections
- From:
Chinese Journal of Obstetrics and Gynecology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate chromosomal gains and losses in association with human papillomavirus status in the vulvar squamous cell carcinomas(VSCC). Methods We analyzed 21 VSCC with comparative genomic hybridization (CGH) and polymerase chain reaction.Results Each case had different degree of variances, including gains and losses of partial or whole chromosome. On average, each case had 4.9(102/21) abnormal regions; losses were more than gains, being respectively 2.6(54/21) and 2.3(48/21). Main variations were gains on chromosomes 3q(43%,9/21),8q(38%,8/21),12q(33%, 7/21 )and 9p(19%,4/21),and losses of 4p(52%,11/21),3p(43%,9/21)and 9p(10%,2/21).Gains of 3q(73%) and 12q(64%) were significantly more common in human papillomavirus (HPV)-positive VSCC compared to HPV-negative VSCC(10%,0;P
