Protective effect of Jinkui Gastric Drug on experimental gastric mucosal lesion and its mechanism
- VernacularTitle:金葵胃药对实验性胃黏膜损伤的保护作用及其机制
- Author:
Wei LIU
;
Huanming HU
;
Xinyi CHAO
;
Cancan JIN
;
Weizhong ZHAO
- Publication Type:Journal Article
- Keywords:
Jinkui Gastric Drug(JK);
gastric mucosal lesion;
protective factor;
rat
- From:
Chinese Traditional Patent Medicine
1992;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the protective effects and its mechanism of Jinkui Gastric Drug(JK). METHODS: The model of gastric mucosal lesion in rats induced by hydrochloride acid-aspirin was used.The indexes of gastric mucosal lesion in JK and control groups were observed.The contents of nitric oxide(NO) and the activity of nitric oxide synthase(NOS) in blood serum and gastric tissue in rats,the levels of 6-keto-PGF_(1?),thromboxane B_2(TXB_2) in blood plasma and epidermal growth factor(EGF) in blood serum were examined. RESULTS: The index of gastric mucosal lesion after administration of JK reduced obviously.The contents of NO and the activity of NOS in serum and gastric tissue increased markedly.The levels of 6-keto-PGF_(1?),TXB_2 and EGF increased significantly. CONCLUSION: JK can protect experimental gastric mucosal lesion and its mechanism may be related to increasing the protective factors.
