Total liquid ventilation reduces lung inflammatory reaction in piglets after cardiopulmonary bypass
- VernacularTitle:完全液体通气减轻乳猪体外循环术后肺炎症反应的实验研究
- Author:
Lijun JIANG
;
Qiang WANG
;
Yinglong LIU
- Publication Type:Journal Article
- Keywords:
Liquid ventilation Extracorporeal circulation Pulmonary ventilation Respiratory distress syndrome
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
1995;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of total liquid ventilation on pulmonary inflammatory reaction in piglets after cardiopulmonary bypass. Methods After receiving cardiopulmonary bypass operation, 12 piglets were randomly treated with conventional gas ventilation or total liquid ventilation for 240 minutes. Samples for blood gas analysis were collected before and at 30-minute interval after cardiopulmonary bypass. The degree of lung injury was analyzed histologically. The inflammatory cells and the levels of interleukin-6, interleukin-8, and myeloperoxidase in bronchoalveolar lavage were analyzed. Results Normal gas exchange was maintained during total liquid ventilation. Nuetrophil and macrophage count in bronchoalveolar lavage and histological lung injury were significantly reduced in the study group. The concentrations of interleukin-6, myeloperoxidase in bronchoalveolar lavage were reduced in the study group [(53.55?15.48) vs. (81.32?15.23) pg/ml, (50.00?7.37) vs. (75.00?9.19) U/L], P
