Study on Chronic Alcoholic Liver Disease Model of Rats
- VernacularTitle:慢性酒精性肝病动物模型的研究
- Author:
Hongbin XIAO
;
Fengyun YAO
;
Xin MU
- Publication Type:Journal Article
- Keywords:
alcoholic liver disease;
animal model
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish alcoholic liver disease (ALD) model of rats. Method Rats were given wine by ig for 13 weeks. ALD were assessed by the level of serum glutamic-pyruvic transaminase (ALT), glutamic oxalacetic transaminase (AST), malonaldehyde (MDA) and pathological changes of liver. Result Over-dose wine can increase the level of serum ALT, AST, and MDA, decrease the level of serum albumin (ALB), and induce hepatic steatosis. Conclusion Alcoholic liver disease model of rats can be established by long-time and over-dose wine. The model can be applied in the research of ALD.
