Determination of the Physical Chemistry Constants of Total Cumarin
- VernacularTitle:祖师麻总香豆素物理化学常数的测定
- Author:
Guiying QIAN
;
Liuqing DI
;
Jinjun SHAN
- Publication Type:Journal Article
- Keywords:
cumarin;
pH value;
solubility;
oil/water detached cofficient
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine pH value, the solubility in different solvents and the oil-water partition coefficients of cumarin. Method UV spectrophotometry was used to determine the content of cumarin. Shake-flask method was developed to determine the oil-water partition coefficients of cumarin. Result The higher solubility values of cumarin were 2 044,2015 and 1969 ?g/mL in acetone , methanol and ethanol, it was almost indiscerptible in water, the limit solubility was 1096.9 ?g/mL, which become stable while the whisk time reached to 8 hours. The oil/water detached coefficient was 11.210, which was higher in acid solvent. Conclusion The method is simple, rapid and reliable.
