EFFECTS OF GANODERMA LUCIDUM POLYSACCHARIDES ON ANTIOXIDANT ABILITY AND MODALITY IN THE HIPPOCAMPUS OF AD RATS
- VernacularTitle:灵芝多糖对阿尔茨海默病大鼠海马组织形态学及抗氧化能力的影响
- Author:
Yanjun GUO
;
Hua YUAN
;
Lina ZHANG
;
Shengwei GAN
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
?-Amyloid polypeptide;
Ganoderma Lucidum Polysaccharide;
Free radicals;
Morris water maze;
Tansmission electron microscopy;
Rat
- From:
Acta Anatomica Sinica
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects and mechanism of Ganoderma Lucidum Polysaccharides (GLP) on the activity of superoxide dismutase(SOD), the content of malondialdehyde(MDA) of hippocampus tissue and the learning and memory ability. Methods AD rats induced by A? 25-35 were treated with GLP for 7 days and then observing the Morris water maze to study the learning and memory ability, the content of MDA, and the activity of SOD was measured in the hippocampus tissue with spectrophotometer. Ultrastructural changes of neuron were viewed under transmission electron microscope. Results GLP can distinctly improve the learning and memory ability of A?-injected rats(P
