EFFECTS OF SELENIUM ON CARCINOGENESIS AND ADRENAL CORTEX OF RAT STOMACH
- VernacularTitle:硒对MNNG诱导大鼠胃癌形成过程中肾上腺皮质酶活性的影响
- Author:
Yanping LI
;
Junmin TANG
;
Yan TANG
;
Fujun SHI
- Publication Type:Journal Article
- Keywords:
Selenium;
Stomach carcinoma;
Adrenal cortex;
Histochemistry;
Flow cytometer;
Rat
- From:
Acta Anatomica Sinica
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the histochemical changes of 3?-hydroxysteroid dyhydrogenase(3?-HSD), sucinic dehydrogenase(SDH) and lipid on rat adrenal cortex in the carcinogenesis-resistance with selentum. Methods Wistar rats stomach carcinogenesis (formation of aneuploid cells in the glandular stomach mucosa) was induced by MNNG(N-methy1-N-nitroso-guanidine,20 mg/kg)gavage. The changes of the adrenal cortex were studied by histochemistry and image analysis during preventing glandular stomach cancer with selenium(0.1 mg/kg and 2.0 mg/kg) Results 1.Dietary Se inhibited the aneuploid cell formation,which induced by MNNG gavage in Wistar rat stomach; 2.The histochemical reactions of 3?-HSD and SDH were both significantly stronger in experimental group than that in normal control group in the course of the rat stomach carcinogenesis(P
