THE EXPRESSION OF SUBSTANCE P AND SUBSTANCE P RECEPTOR IN THE DEVELOPMENT OF MOUSE BRAIN
- VernacularTitle:P物质和P物质受体在小鼠胚胎发育期脑内的表达
- Author:
Hua JI
;
Shu HAN
;
Yi ZHENG
;
Jiangang SUN
;
Shucai LING
- Publication Type:Journal Article
- Keywords:
Substance P;
Substance P receptor;
Neuron development;
Immunohistochemistry;
Mouse
- From:
Acta Anatomica Sinica
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of substance P(SP) and substance P receptor(SPR) during the development of mice brains. Methods The expression of SP and SPR during the development of mice brains from embryonic day(E) 11 to postnatal day(P) 0 days was analyzed by immunohistochemical method. Results The expression of SP began at E11 and gradually increased until birth. The expression of SPR began at E11 and maintained stable expression until birth. SP mostly expressed at striatum and SPR mostly expressed at medullary raphe.Conclusion The expression of SP and SPR during the embryo brain stage may indicate that SP could be an important factor involved in the early organization and maturation of neuron.
