Protective Effect of Combination of Effective Components in Acorus tatarinowii on PC12 Cell Injured by Beta Amyloid Protein
- VernacularTitle:石菖蒲有效成分配伍对A?损伤PC12细胞的保护作用
- Author:
Yong JIANG
;
Yongqi FANG
;
Yuping HE
- Publication Type:Journal Article
- Keywords:
Acorus tatarinowii Schott;
Amyloid beta protein;
?-asarone;
Eugenol;
PC12 cells.
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of ?-asarone combined with eugenol against PC12 cell injury induced by amyloid beta protein (A?25-35) and to explore the advantage of compatibility of monomers in herbs.Methods PC12 cells injury were induced by A?25-35.The morphological features and survival rate of PC12 cells as well as the changes of intracellular Ca2+concentration and NO concentration were observed after administration.Results The optimum combination was 10?mol/L ?-asarone+3 ?mol/L eugenol,which can decrease the concentration of intracellular Ca2+,inhibit the production of NO and increase the survival rate of PC12 cells.Conclusion The combination of effective components in Acorus tatarinowii has a better protective effect on A?25-35-induced PC12 cell injury than Acorus tatarinowii.
