Orthogonal design for optimizing the semi-bionic extraction of Simiao Yongan Decoction
- VernacularTitle:用正交设计优选四妙勇安汤方药的半仿生提取工艺条件
- Author:
Lingjun LI
;
Zhaowang ZHANG
;
Xiumei SUN
;
Weihong XIE
- Publication Type:Journal Article
- Keywords:
Simiao Yongan Decoction;
semi-bionic extraction(SBE);
orthogonal design;
capillary zone electrophoresis;
general evaluation
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the method for using semi-bionic extraction (SBE) on Simiao Yongan Decoction as an example. METHODS: Orthogonal design was used to optimize the extraction conditions of SBE with the evaluation markers such as chlorogenic acid, ferulic acid, glycyrrhizic acid, total polysaccharide, ethanol soluble extractives and dried extract. RESULTS: The optimized SBE conditions were as follows: The medical material was powdered through a sieve with 4 meshes) and extracted with 20% ethanol for three times, the pH of the three extractions were in proper order 3.50, 7.50, 8.50 ; the solvent volume was 10,8,8 times, respectively, and the extraction time was 1.5,1.0,1.0 h, respectively. CONCLUSION: The optimum extraction conditions are stable and practicable, and surpass the original SBE extraction conditions.
