Study on the Relation of Dose and Effect in Treating Diabetic Renal Insufficiency (DRI) with Tangduqing
- VernacularTitle:糖毒清治疗糖尿病肾病肾功能不全的量效学研究
- Author:
Ling ZHAO
;
Cuiqiong QIU
;
Fuhua LU
- Publication Type:Journal Article
- Keywords:
diabetic renal insufficiency;
Tangduqing;
relation of dose and effect
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the best dose of treating diabetic renal insufficiency (DRI) with Tangduqing granules. Methods To establish model rats of DRI by the method of 5/6 nephrectomy and abdominal cavity injection with streptozotocin. The successful model rats with DRI were divided into four groups randomly:model group, high dose group, medium dose group, low dose group. Ten age-matched healthy male SD rats were served as controls (administered with NS 2 mL/d). Ten weeks later, contents of the BUN, SCr and urine protein excretion in 24 hours were determined. And to detect the best dose of treating DRI with Tangduqing granules by evaluating the effect of Tangduqing. Results Tangduqing had the function of reducing contents of BUN, SCr and urine protein excretion in 24 hours of rats with renal insufficiency. Conclusions Tangduqing may effectively delay the development of renal failure. The therapeutic effects of medium dose group were the best.
