Impact of rat skin stratum corneum on transdermal absorption characteristic of Sinomenine Liposome Patch
- VernacularTitle:大鼠皮肤角质层对青藤碱脂质体贴剂透皮吸收的影响
- Author:
Yingfeng ZHANG
;
Xiaogen WANG
;
Liling ZHOU
- Publication Type:Journal Article
- Keywords:
Sinomenine Liposome Patch;
tape stripping;
stratum corneum (SC);
transdermal absorption
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of skin stratum corneum on transdermal absorption characteristic of Sinomenine Liposome Patch. Methods The normal and stripped stratum corneum skin of back and abdomen was used to study the transdermal absorption characteristic by Franz method. The transdermal absorption sample was taken at the preset sampling time point. The sample content was determined by HPLC. The cumulative transdermal amount of per unit area was fitted with sampling time point, the transdermal rate constant (J value) was selected as comparative standard. Results The transdermal rate constant (J) of skin with stratum corneum stripped increased obviously than that of the normal skin, so was the released rate constant. Conclusion The skin stratum corneum has an notable impact on transdermal absorption characteristic of Sinomenine Liposome Patch. When the skin of experimental animal being prepared, the integrality should be paid more attention.
