Experimental Study on Antianxietic Action of Xiaoyao San and Dan Zhi Xiaoyao San
- VernacularTitle:逍遥散和丹栀逍遥散抗焦虑作用的实验研究
- Author:
Zhiwei XU
;
Wenzhu WANG
;
Junfang SU
;
Can YAN
;
Lili WU
- Publication Type:Journal Article
- Keywords:
XIAOYAO SAN /pharmacology;
DAN ZHI XIAOYAO SAN/pharmacology;
DEPRESSION/TCD therapy;
ANXIETY DISORDERS/TCD therapy;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To investigate the antianxietic action of Xiaoyao San(XS)and Dan Zhi Xiaoyao San(DZXS).【Methods】 Wistar rats were randomized into 5 groups: model control group,high-and low-dose DZXS groups(14.4?g/kg and 7.2?g/kg respectively),and high-and low-dose XS groups(21.06?g/kg and 10.53g/kg respectively).Social interaction test and open-field test were carried out to observe the antianxietic action of XS and DZXS.Except that the model group was given normal saline,the rats in other groups were given the corresponding drugs according to the experimental design for 14 successive days.After treatment,the activities within 5 min were monitored by two observers and then the mean value were calculated.【Results】High-and low-dose DZXS prolonged rats social interaction time and increased the times of body erection and dressing their hair,and low-dose XS also increased the times of body erection and dressing their hair(P
