Influence of Temperature and Perfusate Modifier on In-vitro Mass Transfer Coefficient of Microdialysis with Sinomenine as a Model Drug
- VernacularTitle:温度及灌流液改性剂对青藤碱微透析探针体外物质转移系数的影响
- Author:
Yingfeng ZHANG
;
Liling ZHOU
- Publication Type:Journal Article
- Keywords:
SINOMENINE/chemistry;
MICRODIALYSIS;
CHROMATOGRAPHY,HIGH PERFORMANCE LIQUID
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To observe the influence of temperature and perfusate modifier on in-vitro mass transfer coefficient of microdialysis with sinomenine as a model drug.【Methods】The in-vitro relative recovery(RR) was assayed by HPLC at different temperatures and in perfusate including different concentrations of alcohol,and then the mass transfer coefficient was calculated.【Results】In-vitro RR increased with the temperature and the concentrations of alcohol,so did the mass transfer coefficient.【Conclusion】Temperature and alcohol at different concentrations have an effect on RR and mass transfer coefficient of microdialysis with sinomenine as a model drug.
