Lung tissue expression of TLR4 and airway hyperresponsiveness in the mice infected by respiratory syncytial virus
- VernacularTitle:小鼠呼吸道合胞病毒感染肺TLR4表达与气道高反应性
- Author:
Rui LI
- Publication Type:Journal Article
- Keywords:
RSV;
TLR4;
AHR
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the lung tissue TLR4 expression and airway hyperresponsiveness(AHR) in the mice infected by respiratory syncytial virus(RSV).Methods:16 clean,6 weeks old BALB/c mice were divided into two groups equally(RSV group and control).One week after RSV infection,AHR was detected by inhaling the increased concentration of methacholine,TLR4 mRNA expression was measured by RT-PCR methods,and the correlation between AHR and TLR4 expression was also analyzed.Results:An important difference was detected in two groups' airway resistance when the inhaled concentration of methacholine was 3.2g/L(P
