Expression of Skp2,c-Myc and P27~(kip1) protein in colorectal cancer tissue and their correlation
- VernacularTitle:Skp2、c-Myc和P27~(kip1)蛋白在大肠癌组织中的表达及相关性研究
- Author:
Wei NIE
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Skp2 protein;
c-Myc protein;
P27kip1 protein;
Ubiquitin-proteosome pathway
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
Objective: To investigate the expression of Skp2,c-Myc and P27kip1 protein,their association with clinicopathological features and the correlation between one and another.Method:Skp2,c-Myc and P27kip1 protein were examined by using immunochistochemical staining method in 20 cases of normal colorectal mucosa,20 cases of colorectal adenomatous polyp and 60 cases of colorectal cancer,and analysed the relationship with clinicopathologic features and between Skp2 with c-Myc and P27kip1 protein.Results:The positive rates of Skp2,c-Myc and P27kip1 protein in colorectal cancer were 71.67%,66.67% and 21.67% respectively.Moreover,the expression levels of Skp2 and P27kip1 protein in colorectal cancer were significantly associated with the pathologic grade,invasion deep,clinical stage and lymph node metastasis,c-Myc associated with the invasion deep,clinical stage and lymph node metastasis,but were independent of age and sex.Besides,in colorectal cancer,the expression levels of Skp2 and P27kip1 protein were inversely correlated,and the expression levels of Skp2 and c-Myc protein were positively correlated.Conclusions:The expression of Skp2,c-Myc and P27kip1 protein are associated with occurrence and development in colorectal cancer through their alteration,which is very important for assessment of malignancy degree and prognosis in colorectal cancer,and detection cancer of their expression provides theoretical basis for targetting therapy of colorectal.
