Changes in neural stem cell proliferation after rat cerebral ischemia/reperfusion injury is treated with mild hypothermia
- VernacularTitle:亚低温处理大鼠脑缺血再灌注损伤后神经干细胞增殖的动态变化
- Author:
Guoxiang WU
;
Chengyan LI
;
Chunying LIU
;
Jun XIA
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia, reperfusion injury;
Hypothermia;
Neural stem cells
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study changes in neural stem cell proliferation in ischemic brain tissue after cerebral ischemia/reperfusion injury treated with mild hypothermia. Methods The middle cerebral arteries (MCA) of Sprague-Dawley rats were occluded for 2 hours, then reperfused for 3, 7, 11, 14, 18 and 28 days. Using immunohisto-chemical staining, the bromodeoxyur-idine ( BrdU)-positive cells in the brain tissue of the operationally intervened side were examined in a sham-operation group, a control group, and in rats treated using mild hypothermia. Results There were a few BrdU-positive cells in the sham-operated rats, but there were obviously more in the mild hypothermia group than in the control group. The peak period for proliferation of neural stem cells in the ischemic brain tissue was longer in the mild hypothermia group than that in the control group. Conclusion Mild hypothermia may promote proliferation of neural stem cells in ischemic brain tissue after cerebral ischemia/reperfusion injury.
