Expression and significance of soluble fms-like tyrosine kinase 1 in preeclampsia placenta
- VernacularTitle:可溶性血管内皮生长因子受体1在子痫前期患者胎盘组织中的表达及意义
- Author:
Yuanhua YE
;
Ling LIU
;
Ying ZHAN
;
Wei PENG
- Publication Type:Journal Article
- Keywords:
Pre-eclampsia;
Placenta;
Vascular endothelial growth factor A;
Vascular endothelial growth factor receptor-1
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of serum soluble fms-like tyrosine kinase 1 ( sFlt-1 ) in preeclampsia placenta. Methods Immunohistochemistry and semi-quantitative RT-PCR were used to investigate the expression of sFlt-1 and sFlt-1 mRNA in placenta of 30 women with preeclampsia (including mild and moderate preeclampsia 11 cases, severe preeclampsia 19 cases) and 45 normal pregnant women (including first trimester pregnancy 18 cases, 2nd trimester pregnancy 12 cases, and 3rd trimester pregnancy 15 cases). The levels of vascular endothelial growth factor(VEGF) and sFlt-1 in serum were detected by enzyme linked immunosorbent assay. Results (1) The expression of sFlt-1 mRNA was significantly higher in preeclampsia group (0. 90?0. 11) compared with the third trimester group (0. 80?0. 06; P
