Effects of Yupingfeng Powder on Th1/Th2 balanace in murine model of allergic rhinitis
- VernacularTitle:玉屏风散对过敏性鼻炎动物模型的Th1/Th2影响
- Author:
Jun GU
;
Chaobin SHEN
;
Lei LU
;
Qiang DAI
;
Kuangcheng XIE
;
Shengrong ZHONG
;
Yufa WANG
- Publication Type:Journal Article
- Keywords:
allergic rhinitis,Yupingfeng Powder(YPFP),Th1/Th2,animal models
- From:
Chinese Traditional Patent Medicine
1992;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of Yupingfeng Powder(YPFP) on rat's allergic rhinitis induced by stimulating ovalbumin.and reveal the influence on Th1,Th2 and Th1/Th2 proportion. METHODS: 8-week-old BALB/c mice were sensitized by means of intranasal and systemic intraperitoneal injection application of OVA,6 subjects were administered including 2,500 mg/kg extracts of YPFP for 7 days in early stage(interference group);6 mice were administered YPFP in after challenge(therapy group);the placebo group were given saline.After 7 days,Th1 and Th2 in splenocyte were detected by flow cytometry(FCM) and nasobuccal mucosa pathology were observed. RESULTS: When compared with Th2 of animal model group(9.86?1.40),there was a significant decrease expressing Th2 after PFP treatment(3.41?0.72,P
