Effects of Zhiyu Granules on sciatic nerve function of diabetic peripheral neuritis
- VernacularTitle:蛭萸颗粒对糖尿病周围神经炎坐骨神经功能的影响
- Author:
Xiaochen ZHANG
;
Yi YUAN
;
Yihe CHEN
;
Wenjuan WANG
- Publication Type:Journal Article
- Keywords:
Zhiyu Granules;
diabetic peripheral neuritis;
inositol;
Na~+-K~+ pump;
antioxidation;
electric microscope;
rat
- From:
Chinese Traditional Patent Medicine
1992;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To discuss the mechanism of action of Zhiyu Granules on treating diabetic peripheral neuritis. METHODS: The model of diabetic peripheral neuritis in mice was induced by streptozotocin.The effect of Zhiyu Granules on the contents of sciatic nerve inositol in model mice through ELSD(evaporative light scattering detector) was examined,and the activity of Na~+-K~+ pump in sciatic nerve was measured,and the activity of SOD and the contents of MDA in erythrocytes were detected,and the ultrastructures of sciatic nerve,pancreas and kidney in model mice were observed by electric microscope. RESULTS: Zhiyu Granules could increase the contents of sciatic nerve inositol in model rats,and enhance the activity of Na~+-K~+ pump,and improve the ultrastructures of sciatic nerve and pancreas cell.Zhiyu Granules couldn't improve the ultrastructure of renal corpuscles,or affect the activity of SOD and the contents of MDA in erythrocytes of model mice yet. CONCLUSION: Zhiyu Granules is effective in clinical treatment of diabetic peripheral neuritis.
