Effect of Fangjifulingtang on Proliferation and PAI-1 in Glomerular Mesangial Cells
- VernacularTitle:防己茯苓汤加减对TNF-?诱导的大鼠肾小球系膜细胞增殖及PAI-1含量的影响
- Author:
Rong YU
;
Xiaobai ZHANG
;
Xiaodong WEN
- Publication Type:Journal Article
- Keywords:
Fangjifulingtang;
TNF-?;
glomerular mesangial cells;
proliferation;
PAI-1
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Fangjifulingtang on preventing proliferation of glomerular mesangial cells and the expression of PAI-1, so as to provide experimental evidence for Fangjifulingtang to cure chronic kidney disease. Method Glomerular mesangial cells were cultured and TNF-? was used as a stimulation to make the cells proliferate. Then Fangjifulingtang was incubated together at different doses. Cell vitality were evaluated and qualified by MTT. Cell period were analysed by Flow CytoMeter (FCM). Secretion of PAI-1 expression was measured by ELISA. Results The proliferation of Glomerular mesangial cells was inhibited (P
