Effect of Shenfuhuang Injection on Tissue and Plasma Tumor Necrosis Factor ? Level in Septic Rats
- VernacularTitle:参附黄注射液对脓毒症大鼠组织和血浆致炎因子TNF-?水平的影响
- Author:
Lei WANG
;
Qingquan LIU
;
Xueqi ZHU
- Publication Type:Journal Article
- Keywords:
Shenfuhuang injection;
tumor necrosis factor ?;
DAO;
sepsis:multiple organ dysfunction syndrome
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of Shenfuhuang injection (SFH) on tissue and plasma TNF-? level and multiple organ dysfunction in septic rats. Method Wistar rats were subjected to sepsis by ceral ligation and puncture, then they were randomly divided into four groups, normal control, sham operation grop, septic group, SFH group. Animals were sacrificed at 2, 8, 24, 48 h. TNF-? level of lung, liver and plasma were measured. DAO activity was determined. Result TNF-? level of liver, lung and plasma were markedly increased at 2～8 h post-CLP compared with sham operation group. In SFH group, TNF-? level decreased in different degrees. DAO activity was much lower in SFH group than in CLP group at 2, 8 h. Conclusion Early applying of SFH could markedly inhibit TNF-? level of vital organs and injury of intestine, thereby preventing the development of excessive inflammation response and subsequent multiple organ dysfunction syndrome associated with CLP-induced sepsis.
