Experimental Study on the Anti-arrhythmic Effect and the Safety of Plumula nelumbinis Microcapsules
- VernacularTitle:莲子心微囊的安全性及实验性抗心律失常作用
- Author:
Xiaohong YUAN
;
Zhifeng WU
- Publication Type:Journal Article
- Keywords:
Plumula nelumbinis microcapsules;
Anti-arrhythmic;
Mice;
Rats;
Chloroform;
Barium chloride
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the safety of Plumula nelumbinis microcapsules and its anti-arrhythmic effect.Methods Acute toxicity test in mice,arrhythmia mice models induced by chloroform and arrhythmia rats models induced by barium chloride(BaCl2)were adopted.Results The maximum tolerance dose for mice was 16.0 g/kg body weight.The microcapsule decreased the incidence of chloroform-induced ventricular fibrillation in mice significantly(P 0.05,compared with the blank control group).Conclusion The preliminary results show that Plumula nelumbinis microcapsule is safe,and exerts anti-arrhythmic effect against experimental arrhythmia.
