Protective Effects of Huangqi Sanxian Decoction on Central Nervous System of Ovariectomized Rats
- VernacularTitle:黄芪三仙汤对去卵巢大鼠中枢神经的保护作用
- Author:
Zhikun ZHOU
;
Hongbin ZENG
;
Chao CHEN
- Publication Type:Journal Article
- Keywords:
Invigorating kidney and activating blood;
Ovariectomy;
Artrocyte;
Interleukin-6;
Estradiol;
Neuroprotective
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Huangqi Sanxian Decoction,an invigorating kidney and activating blood Chinese medicine,on ultramicrostructure of brain immunocyte of ovariectomized rats.Methods Fifty female rats were randomized into five groups:sham operated group,model group,high-dosage treatment group,low-dosage treatment group and Naofukang control group.The rats models in these groups were established by excising two ovary from dorsal incision,and the same size of fat was excised in the sham operated group.The treatment groups were administrated Huangqi Sanxian Decoction by gastric gavage,the period of treatment for 4 weeks.The status of hippocampal artrocytes,the level of interleukin-6 and serum estradiol were observed after treatment for 4 weeks.Results Ovariectomy can induce hyperplasia of hippocampal artrocytes in the central nervous system,while Huangqi Sanxian Decoction can reduce the artrocyte number,increase the estradiol level and decrease the interleukin-6 level in a dose-dependent manner.Naofukang control group showed no influence on estradiol level.Conclusion Huangqi Sanxian Decoction can inhibit the artrocyte hyperplasia and inflammatory responses in the hippocampas of central nervous system.It exerts protective effects by increasing the estradiol level probably.
