Effects of Different Transdermal Enhancers on Percutaneous Absorption of Ephedrine in Compound Herba Ephedrae Adhesive Plaster
- VernacularTitle:不同透皮促进剂对复方麻黄贴剂中麻黄碱透皮吸收的影响
- Author:
Linmei PAN
;
Jing SHEN
;
Liwei GUO
- Publication Type:Journal Article
- Keywords:
Compound Herba Ephedrae Adhesive Plaster;
Ephedrine;
Transdermal enhancer;
Percutaneous absorption
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different transdermal enhancers on percutaneous absorption of ephedrine in Compound Herba Ephedrae Adhesive Plaster.Methods Using modified Franz diffusion cell,the ephedrine content was determined to investigate the effect of different transdermal enhancers in promoting percutaneous absorption.Results Azone or azone used together with other transderml enhancers had a better effect in promoting percutaneous absorption,indicating that azone was the leading transderml enhancers for ephedrine.The mixed transdermal enhancer of azone and propylene glycol was the most effective combination and the rate constant of percutaneous absorption is 94.280 ?g?cm-2?h-1.Conclusion The mixture of azone and propylene glycol can enthance the percutaneous absorption of ephedrine and can be used as the transdermal enhancers for this compound plaster.
