Effects of Shenqi Compound Recipe on the expression of adiponectin in white adipose tissue in GK rats
- VernacularTitle:参芪复方对GK大鼠白色脂肪组织脂联素基因表达的影响
- Author:
Hongmin ZHANG
;
Shiwei CHEN
- Publication Type:Journal Article
- Keywords:
Shenqi Compound Recipe;
Type 2 diabetes melliutus;
low-grade-inflammation adiponectin;
GK rats
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the anti-low-grade-inflammation mechanisms of Shenqi Compound Recipe(SQCR) in GK rats. METHODS: Specefic pathogen free(SPF) GK rats were divided randomly according to blood glucose level into four groups:Model,Ramipril,SQCR low dosage,SQCR high dosage group and normal Wistar rats(normal control group).GK rats were injected N-?-nitrol-L-arginine methyl ester(L-NAME) intra-peritoneally and took high-fat diet and Wistar rats were injected saline intra-peritoneally and took common diet freely,respectively.In the experiment periods,each group was administrated correspondent substance respectively for 32 days.Serum concentrations of C reactive protein(CRP) and adiponectin were determined by ELISA.Adiponectin mRNA expressions in white adiposed tissue were measured by real time reverse transcriptase PCR. RESULTS:Concentrations of CRP all decreased(P
