The Association between Urine Albumin to Creatinine Ratio and Osteoporosis in Postmenopausal Women with Type 2 Diabetes.
- Author:
Ye Yeon LEE
1
;
Han Byul KIM
;
Jong Won LEE
;
Gyu Min LEE
;
Sang Yoon KIM
;
Ji An HUR
;
Ho Chan CHO
Author Information
- Publication Type:Original Article
- Keywords: Albumins; Creatinine; Diabetes mellitus type 2; Osteoporosis postmenopausal
- MeSH: Albumins; Bone Density; Bone Diseases; Bone Diseases, Metabolic; Creatinine*; Female; Humans; Incidence; Kidney Failure, Chronic; Osteoporosis*; Prevalence; Proteinuria
- From:Journal of Bone Metabolism 2016;23(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Osteoporosis is a progressive bone disease that is characterized by a decrease in bone mass density and destruction of microstructure, which can lead to an increased risk of fracture. Although many studies have been published about the relationship between end-stage renal disease and osteoporosis, research on the relationship between proteinuria and the prevalence of osteoporosis is still lacking. METHODS: We assessed 91 postmenopausal women with type 2 diabetes who visited our hospital from January 2009 to January 2012. RESULTS: Among 91 patients, the prevalence of osteoporosis and osteopenia was 35.2% (32 cases) and 32.9% (30 cases) according to bone mineral density. The patients with microalbuminuria and macroalbuminuria (urine albumin-to-creatinine ratio [UACR] > or = 30) had a significantly higher incidence of osteoporosis compared to subjects with normoalbuminuria (P<0.05). CONCLUSIONS: This study indicates that UACR may be a useful biomarker for increased risk of osteoporosis in postmenopausal women with type 2 diabetes who have been linked to higher UACR levels.
