Study of Pharmacokinetic Properties for ~(99m)Tc-MAG_3-ASON
- VernacularTitle:~(99m)Tc-MAG_3-ASON药代动力学研究
- Author:
Jiajun HUANG
- Publication Type:Journal Article
- Keywords:
Pharmacokinetics;
Half-life;
Antisense oligonucleotide(ASON);
Mercaptoacetylglycylglycylglycine(MAG3);
99mTc-MAG3-ASON
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the pharmacokinetic properties of 99mTc-labeled chelic polymer of MAG3-ASON.Methods: Chelic polymer of 99mTc-MAG3-ASON was prepared according to former methods.Subsequently,this chelic polymer change of concentration was determined by radioactivity counts per minute(CPM),and its half-life of distribution(T1/2?),the half-life of elimination(T1/2?),the central compartment volume of distribution(Vc),the total apparent volume of distribution(Vd) and the total rate of clearance(CL) were calculated by means of 3P97 software.Finally,its rate of binding to serum protein was measured by trichloroacetic acid precipitation.Results: The T1/2?,the T1/2?,the Vc,the Vd and the CL were 2.11min,95.19min,114.9ml,2430.8ml and 17.7ml/min,respectively.After being incubated with fresh human serum for 1.5h,its rate of binding to serum protein was 11.82%.Conclusion: The process of transportation for chelic polymer of 99mTc-MAG3-ASON in vivo is consistent with two-compartment model and it has desirable pharmacokinetic properties.Therefore,it may be used for diagnostic imaging and therapy of cancer.
