Osteoporotic Fracture Risk Assessment Using Bone Mineral Density in Korean: A Community-based Cohort Study.
10.11005/jbm.2016.23.1.34
- Author:
Eun Jin JANG
1
;
Young Kyun LEE
;
Hyung Jin CHOI
;
Yong Chan HA
;
Sunmee JANG
;
Chan Soo SHIN
;
Nam Han CHO
Author Information
1. Department of Information Statistics, Andong National University, Andong, Korea.
- Publication Type:Original Article
- Keywords:
Bone density;
Korea;
Osteoporotic fractures;
Risk assessment
- MeSH:
Arthritis, Rheumatoid;
Body Mass Index;
Bone Density*;
Cohort Studies*;
Female;
Follow-Up Studies;
Humans;
Korea;
Male;
Mass Screening;
Osteoporosis;
Osteoporotic Fractures*;
Risk Assessment*;
Risk Factors;
Smoke;
Smoking
- From:Journal of Bone Metabolism
2016;23(1):34-39
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Fracture-risk assessment tool (FRAX) using just clinical risk factors of osteoporosis has been developed to estimate individual risk of osteoporotic fractures. We developed prediction model of fracture risk using bone mineral density (BMD) as well as clinical risk factors in Korean, and assessed the validity of the final model. METHODS: To develop and validate an osteoporotic FRAX, a total of 768 Korean men and women aged 50 to 90 years were followed for 7 years in a community-based cohort study. BMD as well as clinical risk factors for osteoporotic fracture including age, sex, body mass index, history of fragility fracture, family history of fracture, smoking status, alcohol intake, use of oral glucocorticoid, rheumatoid arthritis, and other causes of secondary osteoporosis were assessed biannually. RESULTS: During the follow-up period, 86 osteoporotic fractures identified (36 in men and 50 in women). The developed prediction models showed high discriminatory power and had goodness of fit. CONCLUSIONS: The developed a Korean specific prediction model for osteoporotic fractures can be easily used as a screening tool to identify individual with high risk of osteoporotic fracture. Further studies for validation are required to confirm the clinical feasibility in general Korean population.
