Effects of Fu fang Tang Yang You on the formation of proliferation scars of rabbits
- VernacularTitle:复方烫疡油对兔耳瘢痕形成的影响
- Author:
Cong LUO
- Publication Type:Journal Article
- Keywords:
Emodin;
Wound;
Scar;
Healing
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of Fu Fang Tang Yang You(复方烫疡油) on the formation of proliferation scars at the ventral side of the ear of rabbits and to explore its possible mechanism.Methods: 144 wounds at the ventral side of the ears of 18 New Zealand white rabbits were created,The area of each wound was 1.2cm?1.0cm.The wounded rabbits were randomly divided into two groups(groups A and B).All the wounds on the right ears of the rabbits in group A were treated with FTY;and the wounds on the left with vegetable oil.All the wounds on the right ears of group B were treated with Sulfadiazine silver cream;and the wounds on the left with normal saline.Tissues from the wounds were examined respectively.30d,60d,90d after injury.Each sample was immunohistochemically stained and examined TGF-?1,type of collagenⅠ?Ⅲ and proliferating cell nuclear antigen(PCNA) monoclonal antibody were examined.The apoptosis index was calculated with TUNEL technique.Results: In FTY group,the time of wound healing was reduced by about 1.5 days;The expression of TGF-?1?PCNA in the tissues of the wounds was lower than that of the control group.Meanwhile,the apoptotic index of fibroblasts was obviously higher than that of the control group.Conclusion: FTY can promote wound healing with less scar formation.
