Ovarian response to gonadotropin stimulation depends on the level of follicle stimulating hormone receptor on granulosa cells
- VernacularTitle:超排卵周期卵巢的反应性与卵泡颗粒细胞中卵泡刺激素受体表达的关系
- Author:
Jie CAI
;
Huijuan GAO
;
Hefeng HUANG
- Publication Type:Journal Article
- Keywords:
Receptors, FSH;
Superovulation;
Infertility
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of follicle stimulating hormone receptor (FSHR) expression on granulosa cells in ovarian response of women undergoing gonadotropin stimulation. Methods A total of 60 women were recruited and divided into poor, moderate and high responders according to the number of follicles. FSHR expression was detemined by Western blot on granulosa cells obtained by follicular aspiration. The peak levels of serum estradiol (E_2) were meassured by immunofluorescent assay. Results (1) The expression of FSHR was significantly different among the 3 groups, being 0.19?0.07, 0.34?0.16, and 0.45?0.18 for poor, moderate and high responders, respectively(P
