Apoptosis of gastric epithelial cells of Mongolian gerbils induced by Helicobacter pylori involved in the mitochondrial pathway
- VernacularTitle:幽门螺杆菌诱导蒙古沙鼠胃上皮细胞凋亡可能涉及线粒体途径
- Author:
Chunhui LAN
;
Dianchun FANG
;
Quanming ZOU
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Apoptosis;
Mitochondria;
Animal model
- From:
Chinese Journal of Digestion
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of mitochondrial pathway in the apoptosis of gastric epithelial cells induced by H. pylori in Mongolian gerbils. Methods A total of 48 Mongolian gerbils were randomly divided into H. pylori infection and without H. pylori infection groups. Eight animals from each group were killed at 1, 3 and 6 months, and histopathological changes in their stomachs were examined. A flow cytometry was used to measure apoptosis, mitochondrial membrane potential and intracellular free Ca2+ . Results The incidences of intestinal metaplasia and dysplasia in the gastric mucosa with H. pylori infection were significantly higher than those without H. pylori infection (P
