Antitumor Effects of Lentinan Combined with Cisplatin on the Apoptosis Induction in mice bearing Lewis Lung Carcinomas
- VernacularTitle:香菇多糖联合顺铂诱导Lewis荷瘤小鼠肿瘤细胞凋亡的研究
- Author:
Huan JING
;
Yan JIN
;
Chunying LIU
- Publication Type:Journal Article
- Keywords:
Lentinan;
Cisplatin;
tumorcell apoptosis;
electron microscope
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Lentinan(LNT) combined with Cisplatin (DDP) on the apoptosis induction in mice bearing Lewis lung carcinomas (LLC). Methods Lewis lung carcinoma cells (1?107) were subcutaneously inoculated into BALB/c mice. Mice were randomized into control groups and treatment groups. Observe the morphologic views under light microscope (LM) and electron microscope (EM). Results Compared with the control groups, the treatment groups were morphologic characteristic by relatively smaller in size, cell atypia were not evident, pathalogical karyokinesis were less interstitial blood vessel were fewer, while lymphocyte infiltrate into the interstitial. Apoptotic bodies could be seen under EM. Within all treatment groups, LNT+DDP group showed significant difference. Conclusions Lentinan combined with Cisplatin showed significant antitumor effects, and mechanism maybe inducing the tumor cell apoptosis and stimulate the proliferation of lymphocyte.
